Endocrine Abstracts

Patients with acromegaly (PWA) experience higher rates of falls and fall-related injuries than age-matched Canadian adults. Previous studies of standing balance revealed increased sway in PWA compared to healthy controls but failed to control for the effects of the pituitary adenoma. Therefore, the aim of the present study was to determine if acromegaly influenced the neuromuscular control of standing balance. Bipedal standing balance was evaluated in PWA (n=13) in bi...

Acromegaly triggers, and is associated with, peripheral nervous system modifications and joint degenerations, which are considered to impact the walking balance of patients with acromegaly (PWA). Therefore, to better understand if these systemic degenerations impact the transitory adaptations in locomotor patterns of these patients, this study aims to establish the walking balance deficits of PWA. Walking balance was evaluated in PWA (n=8) in biochemical remission and...

Acromegaly, characterized by growth hormone excess, adversely affects the patients’ musculoskeletal and neural systems, consequently impairing physical function. Previous studies have noted walking impairments in patients with acromegaly (PWA). This study aimed to characterize the kinematic and kinetic changes during walking in PWA. Kinematics and kinetics of walking were evaluated in PWA (n=8) in biochemical remission and a control group of patients with non-fun...

Endometriosis is a chronic oestrogen-dependent incurable inflammatory disorder, defined by the presence of endometrial-like tissue outside the uterine cavity that affects 6–10% of women of reproductive age. It is associated with debilitating pelvic pain and subfertility with a significant impact on quality of life and estimated annual costs to the UK of £11.7 billion. Recent findings from our laboratory have shown that there is a shift in cell metabolism from mitocho...

Background: Correct identification of patients with HPA axis dysfunction following trans-sphenoidal pituitary surgery is important. Our centre measures post-operative day 5 0900 h serum cortisol (24 h after the last dose of glucocorticoid) to identify the need for glucocorticoid replacement. This is given if post-operative day 5 0900 h cortisol concentration is <300 nmol/l, until dynamic pituitary function assessment occurs.Methods: Data were reviewe...